Dr Narbeh Melikian

 Professional experience

• More than 25 years of experience
• Consultant Cardiologist, OneWelbeck Heart Health, London, UK (present)
• Consultant Cardiologist, Cleveland Clinic London Hospital, London, UK (present)
• Consultant Cardiologist, King’s College Hospital, London, UK (2010 to present)
• Honorary Senior Lecturer in Cardiology, King’s College London School of Medicine, London, UK (2010 - present)
• Lecturer in Cardiology, King’s College Hospital and King’s College London School of Medicine, London, UK (2007 -2010)
• Visiting Senior Fellow in Interventional Cardiology, Aalst Cardiovascular Centre, Aalst, Belgium (2006 - 2007)
• British Cardiac Society John Parker Fellow, King’s College Hospital, London, UK (2004 -2006)
• Senior Registrar and Registrar in Cardiology, Hammersmith and King’s College Hospitals, London, UK (2000 - 2004)
• General Medical and Cardiology Trainee, London Postgraduate Rotation at Hammersmith, Royal Brompton, St Thomas’ and Guy’s Hospitals, London, UK (1996 - 2000)

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 Sub-specialties

• Complex interventional cardiology (coronary angioplasty / stenting, Intra-vascular ultrasound (IVUS), optical coherence tomogrpahy (OCT))
• Structural cardiac intervention (including closure of PFO, ASD and LAA to prevent stroke)
• Hypertension (high blood pressure)
• Neuro-cardiac disorders (treatment of cardiac disorders to prevent TIA and stroke)

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 Teaching posts

• Member of MBBS examinations committee, King’s College London School of Medicine, London, UK (2014 - present)
• Clinical Advisor MBBS degree programme, King’s College London School of Medicine, London, UK (2012 - present)
• Honorary Senior Lecturer in Cardiology, King’s College London School of Medicine, London, UK (2010 - present)
• Clinical Tutor MMBS students, King’s College London School of Medicine, London, UK (2004 - present)

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 Education

• BSc (Hons) Biochemistry (with First Class Honours), University of London, UK (1993)
• MBBS (Hons) (with Honours in Pathology and Pharmacology), Guy’s & St Thomas’ Hospitals Medical School, London, UK (1996)
• British Cardiac Society (BCS) John Parker Research Fellow (2004 - 2006)
• MD (Res) University of London, UK (2009)
• FRCP (UK), Royal College of Physicians of London (2014)

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 Publications and conferences

• 45+ peer reviewed research articles and 100+ conference presentations - Selected peer reviewed original research publications are listed
• The human coronary vasodilatory response to acute mental stress is mediated by neuronal nitric oxide synthase. Khan SG, Melikian N, Shabeeh H, Cabaco AR, Martin K, Khan F, O'Gallagher K, Chowienczyk P, Shah AM. Am J Physiol Heart Circ Physiol. 2017 Jun 23:ajpheart.00745.2016. doi: 10.1152/ajpheart.00745.2016. [Epub ahead of print]
• Blood Pressure in Healthy Humans Is Regulated by Neuronal NO Synthase. Shabeeh H, Khan S, Jiang B, Brett S, Melikian N, Casadei B, Chowienczyk PJ, Shah AM. Hypertension. 2017 May;69(5):970-976
• Physiological Reduction in Left Ventricular Contractile Function in Healthy Postpartum Women: Potential Overlap with Peripartum Cardiomyopathy. Khan SG, Melikian N, Mushemi-Blake S, Dennes W, Jouhra F, Monaghan M, Shah AM. PLoS One. 2016 Feb 9;11(2):e0147074
• Pulmonary Haemodynamics in Sickle Cell Disease Are Driven Predominantly by a High-Output State Rather Than Elevated Pulmonary Vascular Resistance: A Prospective 3-Dimensional Echocardiography/Doppler Study. Mushemi-Blake S, Melikian N, Drasar E, Bhan A, Lunt A, Desai SR, Greenough A, Monaghan MJ, Thein SL, Shah AM. PLoS One. 2015 Aug 13;10(8):e0135472
• Fractional Flow Reserve in the Transradial Era: Will Hand Vein Adenosine Infusion Suffice?: A Comparative Study of the Extent, Rapidity, and Stability of Hyperemia From Hand and Femoral Venous Routes of Adenosine Administration. Scott P, Sirker A, Dworakowski R, Paul G, Candilio L, Jahagirdar N, Melikian N, Byrne J. JACC Cardiovasc Interv. 2015 Apr 20;8(4):527-35.
• Fractional flow reserve-guided PCI for stable coronary artery disease. De Bruyne B, Fearon WF, Pijls NH, Barbato E, Tonino P, Piroth Z, Jagic N, Mobius-Winckler S, Rioufol G, Witt N, Kala P, MacCarthy P, Engström T, Oldroyd K, Mavromatis K, Manoharan G, Verlee P, Frobert O, Curzen N, Johnson JB, Limacher A, Nüesch E, Jüni P; FAME 2 Trial Investigators. N Engl J Med. 2014 Sep 25;371(13):1208-17.
• Pulmonary function, CT and echocardiographic abnormalities in sickle cell disease. Lunt A, Desai SR, Wells AU, Hansell DM, Mushemi S, Melikian N, Shah AM, Thein SL, Greenough A. Thorax. 2014 Aug;69(8):746-51
• Differential role of endothelial versus neuronal nitric oxide synthase in the regulation of coronary blood flow during pacing-induced increases in cardiac workload. Shabeeh H, Melikian N, Dworakowski R, Casadei B, Chowienczyk P, Shah AM. Am J Physiol Heart Circ Physiol. 2013 May;304(9):H1277-82.
• Sympathetic activation increases NO release from eNOS but neither eNOS nor nNOS play an essential role in exercise hyperemia in the human forearm. Shabeeh H, Seddon M, Brett S, Melikian N, Casadei B, Shah AM, Chowienczyk P. Am J Physiol Heart Circ Physiol. 2013 May;304(9):H1225-30.
• Renal impairment is associated with coronary heart disease in HIV-positive men. Campbell LJ, Desai M, Hegazi A, Ibrahim F, Melikian N, Hay P, Fox JM, Post FA. HIV Clin Trials. 2012 Nov-Dec;13(6):343-9.
• Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease. De Bruyne B, Pijls NH, Kalesan B, Barbato E, Tonino PA, Piroth Z, Jagic N, Möbius-Winkler S, Rioufol G, Witt N, Kala P, MacCarthy P, Engström T, Oldroyd KG, Mavromatis K, Manoharan G, Verlee P, Frobert O, Curzen N, Johnson JB, Jüni P, Fearon WF; FAME 2 Trial Investigators. N Engl J Med. 2012 Sep 13;367(11):991-1001.
• High cholesterol levels are associated with coronary microvascular dysfunction. Mangiacapra F, De Bruyne B, Peace AJ, Melikian N, Wijns W, Barbato E. J Cardiovasc Med (Hagerstown). 2012 Jul;13(7):439-42.
• Quantitative assessment of coronary microvascular function in patients with and without epicardial atherosclerosis. Melikian N, Vercauteren S, Fearon WF, Cuisset T, MacCarthy PA, Davidavicius G, Aarnoudse W, Bartunek J, Vanderheyden M, Wyffels E, Wijns W, Heyndrickx GR, Pijls NH, de Bruyne B. EuroIntervention. 2010 Apr;5(8):939-45.
• Neuronal nitric oxide synthase and human vascular regulation. Melikian N, Seddon MD, Casadei B, Chowienczyk PJ, Shah AM. Trends Cardiovasc Med. 2009 Nov;19(8):256-62.
• Fractional flow reserve and myocardial perfusion imaging in patients with angiographic multivessel coronary artery disease. Melikian N, De Bondt P, Tonino P, De Winter O, Wyffels E, Bartunek J, Heyndrickx GR, Fearon WF, Pijls NH, Wijns W, De Bruyne B. JACC Cardiovasc Interv. 2010 Mar;3(3):307-14.
• Interference of drug-eluting stents with endothelium-dependent coronary vasomotion: evidence for device-specific responses. Hamilos M, Sarma J, Ostojic M, Cuisset T, Sarno G, Melikian N, Ntalianis A, Muller O, Barbato E, Beleslin B, Sagic D, De Bruyne B, Bartunek J, Wijns W. Circ Cardiovasc Interv. 2008 Dec;1(3):193-200.
• Physiologic lesion assessment during percutaneous coronary intervention. Melikian N, Del Furia F, Di Mario C. Cardiol Clin. 2010 Feb;28(1):31-54.
• Effects of neuronal nitric oxide synthase on human coronary artery diameter and blood flow in vivo. Seddon M, Melikian N, Dworakowski R, Shabeeh H, Jiang B, Byrne J, Casadei B, Chowienczyk P, Shah AM. Circulation. 2009 May 26;119(20):2656-62.
• Severity of coronary arterial stenoses responsible for acute coronary syndromes. Manoharan G, Ntalianis A, Muller O, Hamilos M, Sarno G, Melikian N, Vanderheyden M, Heyndrickx GR, Wyffels E, Wijns W, De Bruyne B. Am J Cardiol. 2009 May 1;103(9):1183-8.
• In vitro and in vivo studies on thermistor-based intracoronary temperature measurements: effect of pressure and flow. Cuisset T, Beauloye C, Melikian N, Hamilos M, Sarma J, Sarno G, Naslund M, Smith L, Van de Vosse F, Pijls NH, De Bruyne B. Catheter Cardiovasc Interv. 2009 Feb 1;73(2):224-30.
• Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. Tonino PA, De Bruyne B, Pijls NH, Siebert U, Ikeno F, van' t Veer M, Klauss V, Manoharan G, Engstrøm T, Oldroyd KG, Ver Lee PN, MacCarthy PA, Fearon WF; FAME Study Investigators. N Engl J Med. 2009 Jan 15;360(3):213-24.
• Direct stenting for stable angina pectoris is associated with reduced periprocedural microcirculatory injury compared with stenting after pre-dilation. Cuisset T, Hamilos M, Melikian N, Wyffels E, Sarma J, Sarno G, Barbato E, Bartunek J, Wijns W, De Bruyne B. J Am Coll Cardiol. 2008 Mar 18;51(11):1060-5.
• Drug-eluting stents: a critique. Melikian N, Wijns W. Heart. 2008 Feb;94(2):145-52.
• The pathophysiology and clinical course of the normal coronary angina syndrome (cardiac syndrome X). Melikian N, De Bruyne B, Fearon WF, MacCarthy PA. Prog Cardiovasc Dis. 2008 Jan-Feb;50(4):294-310.
• The association between saphenous vein endothelial function, systemic inflammation, and statin therapy in patients undergoing coronary artery bypass surgery. Momin A, Melikian N, Wheatcroft SB, Grieve D, John LC, El Gamel A, Marrinan MT, Desai JB, Driver C, Sherwood R, Shah AM, Kearney MT. J Thorac Cardiovasc Surg. 2007 Aug;134(2):335-41
• Determinants of endothelial function in asymptomatic subjects with and without the metabolic syndrome. Melikian N, Chowienczyk P, MacCarthy PA, Williams IL, Wheatcroft SB, Sherwood R, Gale C, Shah AM, Kearney MT. Atherosclerosis. 2008 Mar;197(1):375-82.
• A simple thermodilution technique to assess coronary endothelium-dependent microvascular function in humans: validation and comparison with coronary flow reserve. Melikian N, Kearney MT, Thomas MR, De Bruyne B, Shah AM, MacCarthy PA. Eur Heart J. 2007 Sep;28(18):2188-94.
• Asymmetric dimethylarginine and reduced nitric oxide bioavailability in young Black African men. Melikian N, Wheatcroft SB, Ogah OS, Murphy C, Chowienczyk PJ, Wierzbicki AS, Sanders TA, Jiang B, Duncan ER, Shah AM, Kearney MT. Hypertension. 2007 Apr;49(4):873-7.
• Leptin is an endothelial-independent vasodilator in humans with coronary artery disease: Evidence for tissue specificity of leptin resistance. Momin AU, Melikian N, Shah AM, Grieve DJ, Wheatcroft SB, John L, El Gamel A, Desai JB, Nelson T, Driver C, Sherwood RA, Kearney MT. Eur Heart J. 2006 Oct;27(19):2294-9
• Can the published cost analysis data for delivery of an efficient primary angioplasty service be applied to the modern National Health Service? Melikian N, Morgan K, Beatt KJ. Heart. 2005 Oct;91(10):1262-4.
• Antioxidant potential of intermediates in phenylpropanoid metabolism in higher plants. Castelluccio C, Paganga G, Melikian N, Bolwell GP, Pridham J, Sampson J, Rice-Evans C. FEBS Lett. 1995 Jul 10;368(1):188-92

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 Prizes and awards

• British Cardiac Intervention Society (BCIS) Young Investigator Award Finalist (2009)
• British Cardiac Intervention Society (BCIS) Finalist Young Investigator Award (2009)
• Charles Forster Prize in Cardiology
• Golding Bird Medal and Beaney Prize in Molecular Biology
• Treasurer’s Medal and Tewfik Prize in Surgery
• Lady Margaret Thatcher Prize in Surgery
• Foord Caiger Prize in Histopathology
• Agnes Shore Prize in Biochemistry
• Gowland Hopkins Prize in Biochemistry
• Grainger Prize in Biochemistry
• Guy’s & St Thomas’ Hospitals Scholarship
• National Wolfson Academic Scholarship

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 Professional membership

• Royal College of Physicians
• British Cardiovascular Intervention Society
• British Medical Association

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