HLA-B27

What is being analysed?

HLA-B27, or Human Leukocyte Antigen B27, is a protein that plays a crucial role in the immune system. The analysis involves identifying the presence of HLA-B27 in a person's blood.

 

What does the result mean?

A positive result indicates the presence of HLA-B27 in the blood, which is associated with various autoimmune conditions like ankylosing spondylitis and reactive arthritis. However, it is essential to note that a positive result doesn't confirm a specific diagnosis but may suggest an increased risk.

Why do the analysis?

The analysis is performed to aid in the diagnosis of certain autoimmune diseases, particularly those affecting the joints and spine. It helps healthcare professionals understand the potential risk factors for specific conditions.

When to do the analysis?

HLA-B27 analysis is typically recommended when a person exhibits symptoms of autoimmune diseases, such as persistent joint pain, stiffness, and inflammation. It is also useful in cases where there's a family history of conditions associated with HLA-B27.

What sample is required?

The analysis requires a blood sample, which is usually drawn from a vein in the arm. The blood sample is then sent to a laboratory for testing.

Is any type of prior preparation necessary?

No specific preparation is required before the analysis. However, it is crucial to inform your doctor about any medications you are taking, as certain drugs may affect the test results.

How is it used?

HLA-B27 analysis is used as a supportive tool in conjunction with clinical assessments and other diagnostic tests. It helps healthcare professionals make informed decisions about the presence or risk of certain autoimmune conditions.

What are the normal values?

The normal result is usually negative, indicating the absence of HLA-B27. However, it is essential to interpret results in the context of the overall clinical picture.

What does it mean to have altered values?

A positive result suggests an increased risk for certain autoimmune diseases, but it does not confirm a specific diagnosis. Further evaluation and consultation with a rheumatologist or other specialists are typically needed for a comprehensive diagnosis.

Table of Values

Result  

Interpretation

Positive

Increased risk of autoimmune diseases, consult with a specialist for further evaluation.

Negative

HLA-B27 not detected, but does not rule out the possibility of autoimmune conditions. Additional tests and clinical evaluation may be needed.

Understanding HLA-B27 results requires a collaborative approach between patients and healthcare professionals, considering the broader clinical context for accurate interpretation.