Rearrangement of immunoglobulin genes in B cells

What is analysed in a rearrangement of immunoglobulin genes in B cells test?

Rearrangement of immunoglobulin genes in B cells is a test that detects specific alterations in the genes of B cells. These cells are a type of lymphocytes responsible for producing antibodies.

During their development, it is normal for reordering to occur in specific parts of their DNA, known as immunoglobulin genes. These rearrangements allow B cells to protect against various infections. However, in certain cases, these rearrangements may be associated with diseases such as B-cell lymphoma.

What does the result mean?

In a normal population of B cells, both the cells and their genetic rearrangement profiles are diverse. In lymphoma, B cells from affected tissue (such as blood, bone marrow, or lymph nodes) are identical, as are their genetic rearrangement profiles. This indicates the presence of clonal cells. The test helps establish the diagnosis of B-cell lymphoma and assess disease persistence or recurrence.

Why perform the analysis?

The analysis is used to diagnose B-cell non-Hodgkin lymphomas and also evaluates residual disease or potential relapses after treatment.

When should the analysis be performed?

When there is suspicion of B-cell lymphoma in an individual. It is also carried out to assess treatment effectiveness or possible recurrences.

Is there a required sample?

The sample is obtained from a bone marrow biopsy, biopsy of other tissues, or even a venous blood sample.

Are any preparations needed?

No special preparation is required for this test.

How is it used?

The analysis evaluates B cells in the submitted sample for study and determines whether most genetic rearrangement profiles are identical or not.