Von Willebrand factor

What is being analysed?

Von Willebrand factor (VWF) analysis involves assessing the levels of Von Willebrand factor in the blood. VWF is a protein crucial for blood clotting, as it helps platelets stick together and adhere to blood vessel walls.

What does the result mean?

The result of VWF analysis indicates the quantity of Von Willebrand factor present in the blood. Normal levels suggest proper clotting function, while abnormal levels may signify bleeding disorders like Von Willebrand disease or thrombotic conditions.

Why do the analysis?

VWF analysis is conducted to diagnose bleeding disorders, monitor treatment efficacy, and assess the risk of excessive bleeding during surgeries or childbirth.

When to do the analysis?

VWF analysis is recommended if symptoms of bleeding disorders such as easy bruising, frequent nosebleeds, or prolonged bleeding after injuries occur. It is also advisable before surgeries or invasive procedures to evaluate bleeding risk.

What sample is required?

A blood sample is required for VWF analysis, usually drawn from a vein in the arm using a needle.

Is any type of prior preparation necessary?

No specific prior preparation is necessary for VWF analysis. However, it is advisable to inform the doctor about any medications being taken, as some drugs can affect test results.

How is it used?

VWF analysis is used to diagnose and monitor bleeding disorders such as Von Willebrand disease, assess bleeding risk before surgeries or invasive procedures, and evaluate treatment response in patients with bleeding disorders.

What are the normal values?

Normal values for VWF levels typically range from 50 to 150 IU/dL (international units per decilitre) in adults.

What does it mean to have altered values?

Low VWF levels: Low levels of VWF may indicate Von Willebrand disease or other bleeding disorders, increasing the risk of excessive bleeding.

High VWF levels: Elevated VWF levels may suggest inflammatory conditions, pregnancy, or thrombotic disorders, potentially increasing the risk of blood clots.

Von Willebrand factor analysis results:

Von Willebrand Factor Levels

Interpretation

Less than 50 IU/dL

Indicates low VWF levels, suggesting a bleeding disorder such as Von Willebrand disease.

50 - 150 IU/dL  

Falls within the normal range, indicating adequate clotting function.

Greater than 150 IU/dL

Indicates elevated VWF levels, which may be associated with inflammatory or thrombotic conditions.