Mr Ioannis Christakis

 Professional experience

• More than 10 years of experience
• Consultant Endocrine and General Surgeon, Nottingham University Hospitals NHS Trust (2019 - present)
• Post-CCT Senior Clinical Fellow in Endocrine Surgery, King's College Hospital NHS Foundation Trust, London (2017 – 2019)
• Post-CCT Senior Clinical Fellow in Endocrine Surgery, Oxford University Hospitals NHS Foundation Trust, Oxford ​(2016 – 2017)
• Postdoctoral Fellow in Endocrine Surgery, MD Anderson Cancer Centre, Houston, United States of America (2015-2016)
• Post-CCT Senior Clinical Fellow in Endocrine Surgery, University College London Hospitals NHS Foundation Trust, London (2014 – 2015)
• PhD student, Department of Endocrinology and Investigative Medicine, Imperial College London, London (2011-2014)
• Deanery trainee in General Surgery, General Hospital of Athens “Polikliniki”, Athens (2005-2011)

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 Sub-specialties

• Normocalcemic and normohormonal hyperparathyroidism
• Bilateral neck explorations (non-localised/negative preoperative scans)
• Redo-parathyroidectomy after previously failed neck exploration (persistent or recurrent hyperparathyroidism)
• Minimally invasive parathyroidectomy
• Parathyroid operation for parathyroid cancer
• Thyroid cancer (papillary, follicular, medullary)
• Rare and genetic diseases including Multiple Endocrine Neoplasia (MEN 1 and MEN2)
• Thyroid nodules (retrosternal goitre)
• Neck lumps
• Graves' disease / thyrotoxicosis
• Phaeochromocytoma
• Cushing's syndrome (Hypercortisolism)
• Conn's syndrome (Hyperaldosteronism)
• Extra-adrenal abdominal paraganglioma
• Adrenal malignancies
• Adrenalectomy-minimally invasive (laparoscopic)

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 Teaching posts

• Honorary (Clinical) Assistant Professor, University of Nottingham, School of Medicine (present)
• Founder and Organiser of the Hands-on Simulation Course “Management of Neck Hematoma and Post-operative Hypocalcemia”, Post-graduate Education Centre, City Hospital, Nottingham
• Clinical and Educational supervisor for medical students
• Weekly teaching sessions to medical students, teaching by the bed-side and in operating room, OSCE examiner for medical students
• Supervising research/audit projects of PhD projects, surgical trainees and medical students

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 Education

• Fellow of the European Board of Endocrine Surgery (FEBS Endo), European Union of Medical Specialists Section of Surgery & European Board of Surgery (2017)
•  Doctor of Philosophy (PhD), Endocrinology and Investigative Medicine, Imperial College London (2016)
• Fellow of the Royal College of Surgeons of England, Intercollegiate Specialty Examination (ad eundem) FRCS (Gen Surg) (2012)
• Master in Surgical Sciences, MSc(surg), General Surgery, University of Edinburgh (2012)
• Master of Science (MSc), "Stress and promotion of health", Medical School of University of Athens, Greece (2010)
• Diploma, "Primary and Secondary Hepatobiliopancreatic Cancers: Onchosurgical Approach", Université Européen Paris XI, France (2007)
• Doctor of Medicine (MD), University of Medicine and Pharmacy “Gr. T. Popa”, Iasi, Romania (2003)

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 Publications and conferences

• Understanding the clinical course of genotype-negative MEN1 patients can inform management strategies. Pieterman CRC, Hyde SM, Wu SY, Landry JP, Chiang YJ, Christakis I, Grubbs EG, Fisher SB, Graham PH, Waguespack SG, Perrier ND. Surgery. 2021 Jan;169(1):175-184. doi: 10.1016/j.surg.2020.04.067. Epub 2020 Jul 20.
• Using a Novel Diagnostic Nomogram to Differentiate Malignant from Benign Parathyroid Neoplasms. Silva-Figueroa AM, Bassett R Jr, Christakis I, Moreno P, Clarke CN, Busaidy NL, Grubbs EG, Lee JE, Perrier ND, Williams MD. Endocr Pathol. 2019 Dec;30(4):285-296. doi: 10.1007/s12022-019-09592-3.
• Fluorocholine PET/CT scanning with arterial phase-enhanced CT is useful for persistent/recurrent primary hyperparathyroidism: first UK case series results. Christakis I, Khan S, Sadler GP, Gleeson FV, Bradley KM, Mihai R. Ann R Coll Surg Engl. 2019 Jul 15:1-7. doi: 10.1308/rcsann.2019.0059
• Long-term quality of voice is usually acceptable after initial hoarseness caused by a thyroidectomy or a parathyroidectomy. Christakis I, Klang P, Talat N, Galata G, Schulte KM. Gland Surg. 2019 Jun;8(3):226-236. doi: 10.21037/gs.2018.09.02.
• Children are at a High Risk of Hypocalcaemia and Hypoparathyroidism after Total Thyroidectomy. de Jong M, Nounou H, Rozalén García V, Christakis I, Brain C, Abdel-Aziz TE, Hewitt RJ, Kurzawinski TR. J Pediatr Surg. 2019 Jul 19. pii: S0022-3468(19)30463-4. doi: 10.1016/j.jpedsurg.2019.06.027.
• Seventeen Cases of Primary Hyperparathyroidism in Pregnancy: A Call for Management Guidelines. DiMarco AN, Meeran K, Christakis I, Sodhi V, Nelson-Piercy C, Tolley NS, Palazzo FF. J Endocr Soc. 2019 Feb 20;3(5):1009-1021. doi: 10.1210/js.2018-00340. eCollection 2019 May 1.
• Operation duration and adrenal gland size, but not BMI, are correlated with complication rate for posterior retroperitoneoscopic adrenalectomy for benign diseases. Christakis I, Ng CS, Chen C, Yiin YH, Grubbs EG, Perrier ND, Lee JE, Graham PH. Surgery. 2018 Oct 25. pii: S0039-6060(18)30644-5. doi: 10.1016/j.surg.2018.09.004.
• Comprehensive genomic characterization of parathyroid cancer identifies novel candidate driver mutations & core pathways. Callisia N Clarke, Panagiotis Katsonis, Teng-Kuei Hsu, Ioannis Christakis, Olivier Lichtarge, Nancy Perrier. Journal of the Endocrine Society, September 2018, DOI: 10.1210/js.2018-00043
• Gender Differences in Bone Mineral Density in Patients with Sporadic Primary Hyperparathyroidism. Danica Dopovicec, Angelica Silva, Ioannis Christakis, Naifa Bussaidy, Callisia Clarke, Elizabeth Gardner Grubbs, Jeffrey E. Lee, Nancy D.Perrier. Endocrinology, Diabetes & Metabolism. Aug 2018. DOI: 10.1002/edm2.37
• Establishing a Successful Rat-Model of Duodenal- Jejunal Bypass: a detailed guide. Akalestou E, Genser L, Villa F, Christakis I, Chokshi S, Williams R, Rubino F.. Lab Anim. 2018 Sep 18:23677218797370. doi: 10.1177/0023677218797370
• I Christakis, S Dimas, ID Kafetzis, N Roukounakis. Risk stratification of 282 differentiated thyroid cancers found incidentally in 1369 total thyroidectomies according to the 2015 ATA guidelines; implications for management and treatment. Ann R Coll Surg Engl. 2018 Feb 27:1-6. doi: 10.1308/rcsann.2018.0017.
• Metastasis to the thyroid gland from a tonsil squamous cell carcinoma. Gumaa D, Christakis I, Mihai R. AME Case Rep. 2018 Mar 7;2:7. doi: 10.21037/acr.2018.01.04
• DiMarco A, Christakis I, Constantinides V, Regan L, Palazzo FF. Undiagnosed Primary Hyperparathyroidism and Recurrent Miscarriage: The First Prospective Pilot Study. World J Surg. 2018 Jan 18. doi: 10.1007/s00268-017-4395-7.
• Ye L, Wang W, Ospina NS, Jiang L, Christakis I, Lu J, Zhou Y, Zhu W, Cao Y, Wang S, Perrier ND, Young WF Jr, Ning G, Wang W. Clinical Features and Prognosis of Thymic Neuroendocrine Tumors Associated with Multiple Endocrine Neoplasia Type 1: A Single Center Study, Systematic Review, and Meta-analysis. Clin Endocrinol (Oxf). 2017 Sep 20. doi: 10.1111/cen.13480.
• Ioannis Christakis, Angelica M. Silva, Thinh Vu, Michelle D. Williams, Hubert H.Chuang, , Naifa L. Busaidy, Bryan Fellman, Nancy D. Perrier. The Diagnostic Accuracy of Neck Ultrasound, 4D-Computed Tomography and Sestamibi Imaging in Parathyroid Carcinoma. European Journal of Radiology. 1 August 2017. https://doi.org/10.1016/j.ejrad.2017.07.026
• Ioannis Christakis, Wei Qiu, Samuel M. Hyde, Gilbert J. Cote, Elizabeth G. Grubbs, Nancy D. Perrier, Jeffrey E. Lee. Genotype-Phenotype Pancreatic Neuroendocrine Tumor Relationship in Multiple Endocrine Neoplasia Type 1 Patients: A 23 Year Experience at a Single Institution. Surgery. 2017 Nov 6. pii: S0039-6060(17)30606-2. doi: 10.1016/j.surg.2017.04.044.
• Ioannis Christakis, Angelica Silva, Michelle D Williams, Adam S Garden, Elizabeth G Grubbs, Naifa L Busaidy, Jeffrey E Lee, Nancy D Perrier, Mark Zafereo. Postoperative Local-regional Radiation Therapy in the Treatment of Parathyroid Carcinoma; The MD Anderson Experience of 35 Years. Pract Radiat Oncol. 2017 Jul 21. pii: S1879-8500(17)30175-3. doi: 10.1016/j.prro.2017.05.009
• Christakis I, Zacharopoulou P,Galanopoulos G, Kafetzis ID, Dimas S, Roukounakis N. Inadvertent parathyroidectomy risk factors in 1,373 thyroidectomies—male gender and presence of lymphadenopathy, but not size of gland, independently increase the risk. Gland Surg 2017;6(6):666-674. doi: 10.21037/gs.2017.07.06
• Lee F. Starker, Ioannis Christakis, Jamii St. Julien, Kelly Schwarz, Paul Graham, Elizabeth G. Grubbs, Jeffrey E. Lee, Nancy D. Perrier. Considering Postoperative Functional Hypoaldosteronism Following Unilateral Adrenalectomy. Am Surg. 2017 Jun 1;83(6):598-604.
• Ioannis Christakis, Ilias-Dimitrios Kafetzis, Spiros Dimas, Nikolaos Roukounakis. Pathology findings of 377 patients with differentiated thyroid cancer in a single centre. Hellenic Journal of Surgery (2017) 89:2, 107-114.
• Ioannis Christakis, Rebecca Scott, James Minnion, Joyceline Cuenco, Tricia Tan, Fausto Palazzo, and Stephen Bloom. Measuring the Pharmacokinetic Properties of Drugs with a Novel Surgical Rat Model. J Invest Surg. 2017 Jun;30(3):162-169. doi: 10.1080/08941939.2016.1231856. Epub 2016 Sep 30.
• Ioannis Christakis, John Livesey, Gregory P Sadler, Radu Mihai. Laparoscopic adrenalectomy for Conn’s syndrome is beneficial to patients and is cost effective in England. J Invest Surg. 2017 May 12:1-7. doi:10.1080/08941939.2017.1323055
• Silva-Figueroa AM, Hess KR, Williams MD, Clarke CN, Christakis I, Graham PH, Grubbs EG, Lee JE, Busaidy NL, Perrier ND. Prognostic Scoring System to Risk Stratify Parathyroid Carcinoma. J Am Coll Surg. 2017 Mar 15. pii: S1072-7515(17)30179-5. doi: 10.1016/j.jamcollsurg.2017.01.060
• Qiu W, Christakis I, Stewart AA, Vodopivec DM, Silva-Figueroa A, Chen H, Woodard TL, Halperin DM, Lee JE, Yao JC, Perrier ND. Is estrogen exposure a protective factor for pancreatic neuroendocrine tumours in female patients with multiple endocrine neoplasia syndrome type 1? Clin Endocrinol (Oxf). 2017 Mar 8. doi: 10.1111/cen.13324
• Ioannis Christakis, Naifa Bussaidy, Callisia Clarke, Lily Joy Kwatampora, Carla L. Warneke, Angelica M. Silva, Michelle Williams, Elizabeth Gardner Grubbs, Jeffrey E. Lee, Nancy D. Perrier. Differentiating Atypical parathyroid Neoplasm from Parathyroid Cancer. Ann Surg Oncol. 2016. DOI 10.1245/s10434-016-5248-6
• Ioannis Christakis, Naifa L. Busaidy, Gilbert J. Cote, Michelle D. Williams, Samuel M. Hyde, Angelica M. Silva Figueroa, Lily Joy Kwatampora, Callisia N. Clarke, Wei Qiu, Jeffrey E. Lee, Nancy D. Perrier. Parathyroid carcinoma and atypical parathyroid neoplasms in MEN1 patients; A clinico-pathologic challenge. The Anderson case series and review of the literature. International Journal of Surgery. 31 (2016) 10-16
• Ioannis Christakis, Wei Qiu, Angelica M. Silva, Samuel Hyde, Gilbert J. Cote, Naifa L. Busaidy, Michelle D. Williams, Elizabeth Grubbs, Jeffrey E. Lee, Nancy D. Perrier. Clinical Features, Treatments, and Outcomes of Patients with Thymic Carcinoids and Multiple Endocrine Neoplasia Type 1 Syndrome at MD Anderson Cancer Center. Horm Cancer. 2016 Aug;7(4):279-87. doi: 10.1007/s12672-016-0269-y. Epub 2016 Jun 16.
• Ioannis Christakis, Angelica M. Silva, Lily Joy Kwatampora , Carla L. Warneke, Callisia N. Clarke, Michelle D. Williams, Elizabeth Grubbs, Jeffrey E. Lee, Naifa L. Busaidy, Nancy D. Perrier. Oncologic Progress for the Treatment of Parathyroid Carcinoma. Journal of Surgical Oncology. J Surg Oncol. 2016 Nov;114(6):708-713. doi: 10.1002/jso.24407. Epub 2016 Oct 18.
• I.Christakis, N.Perrier. A Clinical Practice Algorithm for the Treatment of Cervical Hematoma following an Endocrine Surgical Procedure. Surgery. 2016 Dec;160(6):1712-1714. doi: 10.1016/j.surg.2016.04.018. Epub 2016 May 27.
• Wei Qiu, Ioannis Christakis, Angelica Silva, Roland L Bassett, Liyun Cao, Qing H Meng, Elizabeth Gardner Grubbs, Hua Zhao, James C Yao, Jeffrey E Lee, Nancy D Perrier: Utility of chromogranin A, pancreatic polypeptide, glucagon, and gastrin in the diagnosis and follow-up of pancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1 patients. Clin Endocrinol (Oxf). 2016 Sep;85(3):400-7DOI:10.1111/cen.13119
• A.Silva, D. Vodopivec, I. Christakis, G. Lyons, Q. Wei, S. Waguespack, S. M Petak, E. Grubbs, J. E Lee, N. D Perrier. Surgical intervention for primary hyperparathyroidism offers greater bone recovery in patients with sporadic disease compared to those with multiple endocrine neoplasia type 1-related hyperparathyroidism. Surgery. 2017 Jan;161(1):107-115. doi: 10.1016/j.surg.2016.06.065. Epub 2016 Nov 11.
• I. Christakis, E. Potylchansky, A. Silva, J. Nates, P. Prieto, P. Graham, E. Grubbs, J.Lee, N. Perrier. Cervical Hematoma following an Endocrine Surgical Procedure: The MD Anderson Experience. Surgery. 2016 Aug; 160(2):377-83. doi: 10.1016/j.surg.2016.02.024. Epub 2016 Apr 7.
• Akalestou E, Christakis I, Solomou AM, Minnion JS, Rutter GA, Bloom SR: Proglucagon-Derived Peptides Do Not Significantly Affect Acute Exocrine Pancreas in Rats. Pancreas. 2016 Aug;45(7):967-73
• Miras A., Seyfried F., Phinikaridou A., Andia M., Christakis I., Spector A., Botnar A., Leroux CW. Rats fed diets with different energy contribution from fat do not differ in adiposity. Obes Facts. 2014 Oct 1;7(5):302-310
• Christakis I. Georgiou P., Minnion J., Constantinides V., Tan T., Palazzo F., Murphy K., Bloom S. Learning curve of vessel cannulation in rats using CUSUM analysis. J Surg Res. 2015 Jan;193(1):69-76. doi: 10.1016/j.jss.2014.06.048. Epub 2014 Jul 1.
• Stevens JL., Constantinides V., Todd J., Meeran K., Christakis I., Tolley NS., Palazzo F. Do flow Volume loops alter surgical management in patients with a goiter? Clin Endocrinol (Oxf). 2014 Dec;81(6):916-20. doi: 10.1111/cen.12539.
• Constantinides VA, Christakis I, Touska P, Meeran K, Palazzo F. Retroperitoneoscopic or laparoscopic adrenalectomy? A single-centre UK experience. Surg Endosc. 2013 Nov;27(11):4147-52. doi: 10.1007/s00464-013-3009-1. Epub 2013 May 25
• Constantinides V., Christakis I., Touska P., Palazzo F. Systematic review and meta-analysis of retroperitoneoscopic versus laparoscopic adrenalectomy. Br J Surg. 2012 Dec; 99(12):1639-48. doi: 10.1002/bjs.8921. Epub 2012 Sep 28.
• Christakis I., Constantinides V., Tolley N., Palazzo F. Parathyroid Autotransplantation during Thyroid Surgery: How I do it. World Journal of Endocrine Surgery. 2012; 4(3):115-117 DOI : 10.5005/jp-journals-10002-1112
• Christakis I., Michas S., Mouziouras V., Augoustis C., Dimas S. Minimally invasive techniques for giant parathyroid tumors. An oxymoron?, Hellenic Journal of Surgery. 2012; 84 (4), 220-224, DOI: 10.1007/s13126-012-0032-y
• Dimas S., Michas S., Christakis I., Augoustis C., Alevizaki M. Minimally invasive parathyroidectomy in patients with previous neck surgery, Hormones 2012, 11(2):160-165
• Christakis, I., Kafetzis, I., Diamantopoulos, A., & Leoutsakos, V. (2012). Non-endocrine tumors causing endocrine syndromes: a brief review. International Journal of Students' Research, 2(1), 6-9. doi:10.5549/IJSR.2.1.6-9
• Christakis I , Pagkratis M , Varvogli L , Darviri C , Chroussos G. Measuring the stress of the surgeons in training and use of a novel interventional program to combat it, J Korean Surg Soc. 2012 May;82(5):312-6
• Dimas S, Roukounakis N, Christakis I. Minimally Invasive Parathyroidectomy in Patients with Previous Endocrine Surgery. JSLS. 2011 Oct-Dec; 15(4): 499–503. doi: 10.4293/108680811X13176785204111
• Diamantopoulos A, Kafetzis I, Christakis I, Leoutsakos V. The history of the parathyroid glands, Hormones 2011, 10(1):80-84
• Christakis I., Perrier N. (2015) “Recurrent and Persistent Hyperparathyroidism” in Cameron Textbook “Current Surgical Therapy”, 12th Edition”. Elsevier Publications, ISBN: 978-0-323-37691-4
• Christakis I., Abdel-Aziz T. (2015). “Surgery of the adrenal glands” in book: Head and Neck and Endocrine Surgery - From Clinical Presentation to Treatment Success. Springer Publications, ISBN: 978-3-319-27532-1
• Christakis I., Palazzo F. (2012). Minimal Invasive Parathyroidectomy, Tips and tricks in Endocrine Surgery. C. Springer Publications, Springer Publications. ISBN 978-0-85729-982-6
• Christakis I., Constantinides V., Garas G., Joseph J., Tolley N., Palazzo F. (2013). Minimally Invasive Endocrine (Thyroid, Parathyroid, Adrenal) Surgery: Evolution of Operative Techniques, Safety, Effectiveness and Outcomes. Nova Science Publishers. ISBN: 978-1-62948-838-7
• Christakis I., Palazzo F. (2014). Parathyroid Glands: Homeostasis, Disease and Indications for Surgical Treatment. Nova Science Publishers. ISBN: 978-63117-230-4

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 Professional membership

• British Association of Endocrine and Thyroid Surgeons
• American Association of Endocrine Surgeons
• American College of Surgeons
• European Society of Endocrine Surgeons

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