Dr Constantine Alifrangis

 Professional experience

• More than 20 years of experience
• Consultant medical oncologist specialising in urological cancer treatment, The Harley Street Clinic, part of HCA Healthcare UK
• Consultant medical oncologist specialising in urological cancer treatment, The Prostate Centre
• Consultant medical oncologist specialising in urological cancer treatment, LOC - Leaders in Oncology Care
• Consultant medical oncologist specialising in urological cancer treatment, LOC at Chelsea
• Consultant medical oncologist specialising in urological cancer treatment, University College London Hospitals NHS Foundation Trust

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 Sub-specialties

• Penile cancer
• Rare genitourinary cancers
• Advanced prostate cancer

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 Education

• PhD, 'The Link Between Cancer Genetics and the Efficacy of Novel Therapies', University of Cambridge (2014)
• MRCP, Royal College of Physicians
• MB BS, University of London (2005)
• BSc

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 Publications and conferences

• ctDNA monitoring using patient-specific sequencing and integration of variant reads. Wan JCM, Heider K, Gale D, Murphy S, Fisher E, Mouliere F, Ruiz-Valdepenas A, Santonja A, Morris J, Chandrananda D, Marshall A, Gill AB, Chan PY, Barker E, Young G, Cooper WN, Hudecova I, Marass F, Mair R, Brindle KM, Stewart GD, Abraham JE, Caldas C, Rassl DM, Rintoul RC, Alifrangis C, Middleton MR, Gallagher FA, Parkinson C, Durrani A, McDermott U, Smith CG, Massie C, Corrie PG, Rosenfeld N. Sci Transl Med. 2020 Jun 17;12(548):eaaz8084. doi: 10.1126/scitranslmed.aaz8084. PMID: 32554709
• Management of Late Relapses After Chemotherapy in Testicular Cancer: Optimal Outcomes with Dose-intense Salvage Chemotherapy and Surgery. Alifrangis C, Lucas O, Benafif S, Ansell W, Greenwood M, Smith S, Wilson P, Thomas B, Rudman S, Mazhar D, Berney D, Shamash J. Eur Urol Focus. 2020 May 4:S2405-4569(20)30099-7. doi: 10.1016/j.euf.2020.04.001. Online ahead of print. PMID: 32381397
• The Use of Transdermal Estrogen in Castrate-resistant, Steroid-refractory Prostate Cancer. Smith K, Galazi M, Openshaw MR, Wilson P, Sarker SJ, O'Brien N, Alifrangis C, Stebbing J, Shamash J. Clin Genitourin Cancer. 2020 Jun;18(3):e217-e223. doi: 10.1016/j.clgc.2019.09.019. Epub 2019 Oct 10. PMID: 32171601
• The management of patients with learning difficulties and testicular cancer: overcoming barriers to improve care. Mott CE, Ng K, Alifrangis C. BMJ Case Rep. 2019 Nov 13;12(11):e227330. doi: 10.1136/bcr-2018-227330. PMID: 31727635
• Dose-dense chemotherapy for untreated poor-prognosis and relapsed germ-cell tumours: an 18-year experience with GAMEC chemotherapy. Shamash J, Mee M, Sarker SJ, Wilson P, Ansell W, Greenwood M, Berney D, Alifrangis C. BJU Int. 2020 Jun;125(6):843-852. doi: 10.1111/bju.14947. Epub 2020 May 4. PMID: 31688976
• Pathological risk factors for metastatic disease at presentation in testicular seminomas with focus on the recent pT changes in AJCC TNM eighth edition. Scandura G, Wagner T, Beltran L, Alifrangis C, Shamash J, Berney DM. Hum Pathol. 2019 Dec;94:16-22. doi: 10.1016/j.humpath.2019.10.004. Epub 2019 Oct 27. PMID: 3166619
• Somatic Transformation in Metastatic Testicular Germ Cell Tumours - A Different Disease Entity. Sharma A, Alifrangis C, Milic M, Hall M, Vasdev N, Wilson P, Gogbashian A, Hrouda D, Berney D, Shamash J. Anticancer Res. 2019 Sep;39(9):4911-4916. doi: 10.21873/anticanres.13678. PMID: 31519595
• Molecular and histopathology directed therapy for advanced bladder cancer. Alifrangis C, McGovern U, Freeman A, Powles T, Linch M. Nat Rev Urol. 2019 Aug;16(8):465-483. doi: 10.1038/s41585-019-0208-0. Epub 2019 Jul 9. PMID: 31289379 Review.
• Pembrolizumab for Locally Advanced or Metastatic Urothelial Cancer Where Cisplatin is Unsuitable: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. Ren S, Squires H, Hock E, Kaltenthaler E, Rawdin A, Alifrangis C.Pharmacoeconomics. 2019 Sep;37(9):1073-1080. doi: 10.1007/s40273-018-0750-2.PMID: 30547369 Free article. Review.

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 Prizes and awards

• Sylvia Lawler Prize, Oncology section, Royal Society of Medicine