Ask a top neurologist: what is vascular neurology?

Written in association with: Professor Hedley Emsley
Published:
Edited by: Laura Burgess

Professor Hedley Emsley is one of only a few UK neurologists with expertise in vascular neurology as well as general neurology and we were fortunate to ask him all about his specialty, including all of the conditions that he treats in his practice at the Greater Lancashire Hospital in Preston.
 

Model image of a brain

What is vascular neurology?

Vascular neurology is concerned with neurovascular conditions affecting the central nervous system. This is a large field and encompasses common conditions such as stroke and transient ischaemic attack as well as other types of brain blood vessel disease – or cerebrovascular disease – such as cerebral small vessel disease.

Prevention of recurrent stroke depends, in part, on the accurate identification of the underlying cause. This will often be arterial disease such as ‘hardening’ or atherosclerosis, or a heart rhythm problem such as atrial fibrillation, but there are many other causes particularly in younger adults including cervical arterial dissection.

The cause of some strokes will remain unknown despite extensive tests – these are known as cryptogenic. A small proportion of strokes are due to thrombosis involving the veins, a condition known as intracranial venous thrombosis.

Neurovascular conditions include a large number of other disorders such as subarachnoid haemorrhage in which blood leaks beneath the arachnoid membrane of the brain from a major blood vessel. This can be due to trauma or may be spontaneous due to an underlying intracranial aneurysm.

Other conditions include arteriovenous malformation where there is an abnormality of the blood vessel network in which arteries and veins become joined in a haphazard manner. Another type of malformation of blood vessels is a cavernoma, which often form a small round cluster of abnormally enlarged blood vessels.

Conditions such as subarachnoid haemorrhage and arteriovenous malformations are often managed jointly with specialists in neurosurgery and interventional neuroradiology. A variety of other disorders are managed by vascular neurology including cerebral vasculitis where there is inflammation of the blood vessels of the brain.
 

What more can you tell us about cerebrovascular disease?

Cerebrovascular disease can also show itself as late-onset epilepsy, which is known to be associated with an increased risk of stroke. Late-onset epilepsy can be difficult to diagnose because seizures occurring later in life, typically focal seizures, can be more difficult to recognise and distinguish from other causes of transient neurological dysfunction such as transient ischaemic attack, migrainous aura, and the more recently recognised amyloid spells of cerebral amyloid angiopathy.

Interest is growing in cerebrovascular disease because of its role in other neurological conditions such as parkinsonism, including vascular parkinsonism which is usually due to small vessel disease, and idiopathic Parkinson’s disease, where there appears to be an interaction between blood vessel disease and the neurodegenerative process, as well as in dementia, including Alzheimer’s disease, vascular dementia and mixed dementia.


Professor Emsley specialises in treating stroke, cerebrovascular disease, epilepsy, migraine and neurological disorders. You can book an appointment to see him via his Top Doctor’s profile here.

By Professor Hedley Emsley
Neurology

Professor Hedley Emsley is a renowned consultant neurologist practising privately at the Greater Lancashire Hospital in Preston. His areas of expertise include vascular neurologystrokecerebrovascular disease (including small vessel disease, cerebral amyloid angiopathy)late-onset epilepsymigraine and neurological disorders including Parkinson’s disease.

Professor Emsley graduated with an MBChB in 1996 from the University of Manchester. He undertook several junior doctor posts in the North West of England and at the National Hospital for Neurology and Neurosurgery in London before becoming a member of the Royal College of Physicians of London (MRCP) in 1999. He then completed a PhD on inflammation and cytokine regulation in stroke, awarded in 2004, and undertook specialist training as a clinical lecturer in neurology at the Walton Centre for Neurology & Neurosurgery in Liverpool. Before becoming a fellow of the Royal College of Physicians of London (FRCP) in 2012, he obtained both the Certificate of Completion of Training (CCT) in neurology and a postgraduate certificate in clinical education in 2008 (PGCTLCP with distinction). He was made a fellow of the Higher Education Academy (FHEA) in 2012.

Professor Emsley was appointed Consultant Neurologist with special interest in Stroke Neurology at Lancashire Teaching Hospitals NHS Foundation Trust in 2008, and in 2014, he became the Clinical Director for Neurology at the Trust for three years. He has numerous external responsibilities including his current roles on the Epilepsy Research Institute’s Mortality, Morbidity and Risk Task Force, the Association of British Neurologists Advisory Group on Data and Devices, and on the Health Data Research UK (HDR-UK) North Executive Committee. Previous roles include co-chair for the Association of British Neurologists Stroke Advisory Group, clinical advisor to the Neurology Intelligence Collaborative, North West National Institute for Health Research (NIHR) advisory panel member for the Research for Patient Benefit (RfPB) programme, and external examiner for the University College London Stroke MSc programme.

He took up his post as Professor of Clinical Neuroscience at Lancaster University in 2017 alongside his NHS role. He has authored or co-authored more than 200 academic outputs in all including articles in peer-reviewed medical journals, reports, book chapters and conference abstracts. He regularly engages in peer-review and editorial work. He is a chief investigator and a research supervisor on a range of NIHR portfolio studies in stroke and neurological disorders. He has extensive research collaborations and a number of research interests including cerebrovascular disease and its interface with other neurological disorders, inflammation, infection, novel mechanisms, targets, biomarkers and trials in cerebrovascular disease and other neurological disorders, as well as novel uses of routinely collected data. He also serves on Lancaster University’s Research Ethics Committee.

Current collaborations and projects include:

  • work with academic partners on NHS England’s North West Secure Data Environment, a secure data and research analysis platform, including funding to support work on artificial intelligence related work on routinely collected data
  • a collaboration with the Department of Health & Social Care using Hospital Episodes Statistics Data on neurological admissions, comorbidities, including work that has highlighted the prominence of cardiovascular disease as a comorbidity in epilepsy
  • a forthcoming book chapter on Epilepsy in Older Adults in the new edition of leading reference in the field of geriatric care, Brocklehurst's Textbook of Geriatric Medicine and Gerontology
  • establishment of a Collaboration for Late Onset and Vascular Epilepsy Research (CLOVER) in the UK and with international partners
  • work as part on the International Small Vessel Disease Network led by the University of Edinburgh to improve clinical SVD care

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