Expert insights on HoLEP: Effective prostate treatment for lasting results

Written in association with: Mr Nkwam Michael Nkwam
Published:
Edited by: Sophie Kennedy

In this informative article, we hear from esteemed consultant urological surgeon Mr Nkwam Michael Nkwam on holmium laser enucleation of the prostate, or HoLEP, a cutting-edge, minimally invasive surgical technique for the treatment of prostate problems. The revered specialist details how advanced laser technology is used to effectively treat bothersome urinary symptoms, particularly for larger prostates. Mr Nkwam also discusses safety, recovery, and the long-term success rates which afford lasting relief and improved quality of life for men suffering from prostate symptoms.

What is HoLEP?

HoLEP stands for holmium laser enucleation of the prostate. It is a minimally invasive, specialist surgical technique whereby a fine laser fibre is used to peel the prostate away from its outer shell or capsule.


Why would someone require HoLEP?

The HoLEP procedure is, one of if not, the most effective form of bladder outlet surgery there is and lends itself very well to prostates of all sizes.

Men who have bothersome urinary symptoms such as poor flow, dribbling and hesitancy, and of course men who are unable to pass urine at all without the aid of a catheter, have a condition called benign prostatic hypertrophy (BPH). These men would benefit from the HoLEP procedure.

This highly effective laser operation comes into its own for really big prostates (i.e. greater than 80cc in volume). This is because due to the large size of such prostates, standard techniques such as TURP may struggle to remove enough prostate tissue to improve a man’s symptoms sufficiently. Furthermore, if symptom improvement is achieved, they invariably return after some time.


Is HoLEP considered major surgery?

No, HoLEP is a minimally invasive procedure for the treatment of men with BPH. It is considered to be a very safe procedure which can be performed under a general anaesthetic (patient asleep) or a spinal anaesthetic (patient awake but numb from the waist down) and can take anywhere from 45 minutes to three hours to complete depending on the size of the prostate. However, almost all patients are home the day after surgery, catheter-free!


What are the advantages and disadvantages of HoLEP?

The advantages of HoLEP include the ability to deal with prostates of any size. It offers the greatest improvement in symptom relief and urinary flow rate.

Amazingly, only about one per cent of men require a second surgical procedure to improve their symptoms at 10 years, whereas this figure can be as high as fifty per cent with other techniques.

Side effects are much like other surgical prostate procedures and include the following:

Common

  • temporary mild burning sensation on passing urine
  • bloodstained urine
  • retrograde ejaculation

Uncommon

  • temporary short term loss of urinary control - which can be improved with pelvic floor exercises

Rare

  • bleeding requiring blood transfusion or reoperation


How long do the results of HoLEP last? Can the prostate grow back?

Due to the completeness of the enucleation technique, minimal prostate tissue is left behind as it is all peeled off from the prostate capsule. This means there is very little chance for the prostate to grow back and cause recurrence of urinary symptoms. Hence, the results of the HoLEP surgery last up to 10 years in 99 per cent of men.




If you are considering undergoing HoLEP treatment or are experiencing troublesome urinary symptoms, you can schedule a consultation with Mr Nkwam by visiting his Top Doctors profile.

By Mr Nkwam Michael Nkwam
Urology

Mr Nkwam Michael Nkwam is a highly respected consultant urological surgeon based in London. He is renowned for his expertise in benign prostate hyperplasia (enlargement), prostate cancer diagnostics and Holmium laser (HoLEP). He additionally specialises in kidney stones, haematuria (blood in the urine) and vasectomy. His NHS base is at the Princess Royal University Hospital in Farnborough Common, part of King’s College Hospital NHS Foundation Trust, where he was appointed in 2019.  He holds the position of Chair of the Cancer MDT as well as Cancer Lead for Urology and as such has established good working relationships with Consultants and Clinical Nurse Specialists from other specialties such as General Surgery & Gynaecology.
 
Training

Mr Nkwam completed his medical degree at St George's, University of London in 2007, subsequently completing his core surgical training in the West Midlands in 2011. He was awarded his membership of the Royal College of Surgeons of England in 2010, later completing his higher surgical training in Urology in the East Midlands training programme. During his time in the Midlands he garnered experience in all aspects of urology including bladder, prostate and kidney cancers, as well as andrology and female bladder health.  He became a Urological Fellow of the Royal College of Surgeons of England in 2017 and in 2018 he was awarded admission to the General Medical Council’s Specialist Register for Urology.
 
Subspecialist Fellowship Training

Mr Nkwam completed a year-long fellowship in Holmium Laser Enucleation of the Prostate (HoLEP) surgery and Endourology at Luton & Dunstable Hospital, one of the highest volume centres for HoLEP in the UK performing over 200 cases annually.  Here he developed his expertise in performing the HoLEP – widely regarded as the most effective and durable procedure available for men with benign prostatic enlargement.  Shortly after his appointment to King’s College Hospital, London in November 2019 he successfully performed their first ever HoLEP procedure and to date he has performed over 350 cases.
 
Research

Mr Nkwam has clinical expertise in all areas of endourology, general urology and urological oncology.  He is also a keen academic and has presented his work at several national and international conferences.  His research is well published, with over 20 publications in peer-reviewed journals and seven as first author.
 
Throughout his esteemed career, the excellence of Mr Nkwam’s work has been recognised with numerous awards, including ‘Best Poster in Session’ prizes, awarded by the European Association of Urology (EAU) in 2017 and the British Association of Urological Surgeons (BAUS) in 2018.  As a testament to his academic and clinical expertise, he was also awarded the East Midlands Trainee Medal in 2017 and the Ian McCallum Research Prize in 2018 for his work on superficial bladder cancer, in Nottingham.  He is a member of several key professional bodies, including British Urology Researchers in Surgical Training (BURST) and the British Association of Urological Surgeons (BAUS).
 
Lastly, Mr Nkwam has also been awarded a Master of Philosophy (MPhil) for his research thesis on the development of new biomarkers in prostate cancer.
 
Special interests

Following on from his MPhil research, Mr Nkwam has a specialist interest in prostate cancer diagnosis and treatment.  He is an expert in MRI-guided ultrasound fusion transperineal prostate biopsy – a procedure which can be done simply and quicky under local or general anaesthetic in just a few minutes with the added benefit of targeting potential prostate cancers with the help of an MRI scan.  This transperineal approach has the added advantage of greatly reducing the risk of infection following biopsy compared to the standard transrectal route.

In addition to setting up the HoLEP service at King’s, Mr Nkwam also re-launched the Focal Therapy service at the Trust in November 2024 with the introduction of Nanoknife – focal therapy treatment for prostate cancer.  This has the benefit of treating only the part of the prostate with the cancer in it and crucially sparing the rest of the prostate and surrounding critical structures without the need for any hormonal manipulation.  This means significantly reduced side effects for men, such as erectile dysfunction and urinary incontinence, compared to more standard radical treatment options, such as radical prostatectomy or radiotherapy.
 
Mr Nkwam also offers minimally invasive surgical treatments for benign prostate enlargement including Rezum (steam treatment) and prostatic urethral lift implants (Urolift).
 
Mr Nkwam is an excellent listener and prides himself on his clear oral and written communication with patients, and always does his best to go the extra mile for them whenever he can. 
 
In his spare time he enjoys watching and playing football, as well as rugby and Formula One.  However, his favourite past-time is spending time at home with his wife and three young children in south London.

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