NanoKnife: A groundbreaking approach to treating prostate cancer

Written in association with: Mr Marc Laniado
Published: | Updated: 05/02/2025
Edited by: Karolyn Judge

NanoKnife is an innovative treatment for prostate cancer that uses irreversible electroporation (IRE) to target cancerous cells while preserving surrounding healthy tissue. This non-thermal, minimally invasive technique is gaining attention as an alternative to traditional treatments like surgery and radiotherapy, particularly for localised prostate cancer.

 

Man thinking about NanoKnife treatment.

 

How does NanoKnife work?

 

NanoKnife uses pulses of electrical energy to create microscopic holes in cancer cells, leading to their destruction. Unlike other treatments that rely on heat (such as laser or radiofrequency ablation), NanoKnife does not cause thermal damage, which helps preserve critical structures like nerves and blood vessels.

 

 

What are the benefits of NanoKnife for prostate cancer?

 

  • Minimally invasive: Performed using fine needles, reducing the need for open surgery.
  • Preserves surrounding tissue: Reduces the risk of damage to nerves, helping to maintain urinary and sexual function.
  • Short recovery time: Most patients experience faster recovery compared to traditional treatments.
  • Lower risk of complications: Less impact on urinary continence and erectile function compared to surgery or radiotherapy.

 

 

Who is a suitable candidate for NanoKnife treatment?

 

NanoKnife is generally recommended for patients with localised prostate cancer that has not spread beyond the prostate. It may be considered for:

  • Patients looking for a focal therapy approach to target cancer without removing the entire prostate.
  • Those who are not suitable for surgery due to medical reasons.
  • Patients wanting a treatment with fewer side effects on urinary and sexual function.

 

 

What is the recovery process like?

 

  • The procedure is performed under general anaesthesia and typically takes about one to two hours.
  • Most patients can return home the same day or within 24 hours.
  • Normal activities can usually be resumed within a few days, with minimal discomfort.
  • Regular follow-up scans and PSA tests are required to monitor treatment success.

 

 

 

How does NanoKnife compare to other prostate cancer treatments?

 

Treatment

Invasiveness

Recovery Time

Risk of Side Effects

Suitability

NanoKnife (IRE)

Minimally invasive

Quick recovery

Lower risk of incontinence & erectile dysfunction

Localised cancer

Surgery (prostatectomy)

Invasive

Longer recovery

Higher risk of urinary & sexual side effects

Localised & advanced cancer

Radiotherapy

Non-invasive

Gradual recovery

Can cause bowel & urinary issues

Localised & advanced cancer

Hormone therapy

Non-invasive

Ongoing treatment

May cause fatigue & hormonal side effects

Advanced or recurrent cancer

 

 

NanoKnife is an advanced treatment option for localised prostate cancer, offering precise tumour targeting with fewer side effects than traditional methods. While it is not suitable for all patients, those seeking a minimally invasive approach with a quicker recovery may benefit. Consulting a specialist can help determine whether NanoKnife is the right choice based on individual circumstances.

By Mr Marc Laniado
Urology

*Please note that Mr Laniado is still consulting (both face-to-face and remotely) during COVID-19*

 

Mr Marc Laniado offers men with prostate enlargement or early prostate cancer treatments that benefit with less chance of side-effects. He uses the most advanced techniques that have a consistently better success rate. These are personalised to the individual needs and values of each man he sees.

 

Prostate cancer:

  • highly accurate diagnostic tests with the least side-effects (enhanced MRI, transperineal prostate biopsies, and genomic testing)
  • treatments for early prostate cancer that can preserve bladder control and erections more consistently than conventional treatments (focal therapy by HIFU, Retzius-sparing prostatectomy with nerve-sparing (NeuroSAFE), and seeds, a.ka. brachytherapy)
  • active surveillance: close monitoring for men who do not need immediate treatment

Prostate Enlargement (BPH):

  • minimally invasive treatments for small to medium-sized prostate that can improve urinary symptoms and maintain erections & ejaculation (Rezum and UroLift)
  • treatments for large prostates that improve urinary symptoms with a faster and more comfortable recovery (Aquablation, laser prostatectomy, HoLEP)
  • assessment for Prostate Artery Embolisation (PAE) 

 

He is a highly experienced urologist and works full time in the direct clinical care of men with prostate problems. Annually, he performs about 100 Retzius-sparing prostatectomies, as well as HIFU,  and 100 or more treatments for BPH.

 

He is the joint chairman of the prostate cancer multidisciplinary team for private patients at the Wellington Hospital and the Princess Grace Hospital where he operates and sees patients. He also sees patients at The London Clinic.

 

Mr Laniado was appointed as a consultant in 2002 and started performing conventional robotic prostatectomies in 2008. In 2016, He switched to the Retzius-sparing approach because of the much better bladder control and recovery of erections with similar cancer outcomes. He trains surgeons learning how to perform Retzius-sparing prostatectomies at the Royal Berkshire Hospital. NHS patients consult with him at the Royal Berkshire Hospital and Wexham Park Hospital (Frimley Health), where he is the lead for urological cancer.

 

Mr Laniado graduated from Guy's Hospital Medical School in 1989, having previously gained a BSc in physiology. Following specialist urology training in London, he became a Fellow of the Royal College of Surgeons (Urology) in 2000, going on to complete his MD in prostate cancer research, Fellow of the European Board of Urology in 2002, and become an international member of the American Urological Association. Before taking up his career as a consultant, Mr Laniado extended his knowledge and skills on a Visiting Fellowship at the Cleveland Clinic Foundation in the USA, where he trained in minimally invasive surgical techniques. 

 

Mr Laniado chooses treatments wherever possible for prostate problems that maximise the benefit-to-risk ratio, which are often less readily available. However, it is not possible to completely eliminate the chance or impact of after-effects after treatment, although the risk and impact are minimalised as much as possible.

 

 

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