What is cholangiocarcinoma, and where is it found in the body?

Written in association with: Professor Brian Davidson
Published:
Edited by: Conor Lynch

We recently had the pleasure of speaking to highly experienced and skilled consultant surgeon, Professor Brian Davidson, who, here in one of our latest articles, pinpoints for us where exactly cholangiocarcinoma (bile duct cancer) is found in the body, whilst also outlining the causes and surgical and non-surgical treatment options for the cancer.

Where is cholangiocarcinoma found in the body?

They are normally present in the lower end of the bile duct, with signs and symptoms that are strikingly similar to pancreatic cancer symptoms. The majority of bile duct cancers (cholangiocarcinoma) are found when the bile duct rises from the liver. They can also appear in the outskirts of the liver.

 

What causes the development of cholangiocarcinoma?

For the majority of patients, the exact cause is difficult to establish. Most patients develop it spontaneously. There are some conditions that can increase your risk of developing cholangiocarcinoma, such as PSC, which is a chronic condition that causes scarring and inflammation of the bile duct.

 

What are the different types of cholangiocarcinoma?

They are mainly glandular cancers. Sometimes we get different types, but they are usually glandular cancers that develop within the bile duct.

 

Can it be cured?

Yes, cholangiocarcinoma can indeed be cured. It is a complex cure though due to the positioning of the cancer within the bile duct. As a result, surgery may not be possible in some cases.

 

Are there non-surgical treatment options?

The best possible treatment option, if possible, is a surgical resection, where parts of the liver are removed. If the cancer has spread to other parts of the body, chemotherapy is an effective option. Several other forms of treatment, such as thermal ablation, and radiotherapy, are also good options. Transplantation may be an effective option for some patients.

 

Professor Brian Davidson is a highly revered consultant surgeon who specialises in liver cancer and bile duct cancer. Consult with him today via his Top Doctors profile if you are concerned about possibly having the cancer

Professor Brian Davidson

By Professor Brian Davidson
Surgery

Professor Brian Davidson is a world-leading consultant in hepato-pancreatico-biliary (HPB) and liver transplant surgery in Central London. He is based at the Royal Free Hospital in Hampstead, where he has worked for over 30 years, and is on the liver unit team at The Wellington Hospital in St John's Wood, Westminster.

He specialises in liver resectionbiliary tract and pancreatic surgery, particularly the Whipple procedure. This procedure is a complex operation used to treat tumours and other disorders of the pancreasintestine and bile duct. He also has particular interest in the use of laparoscopic surgery to treat gallbladder, spleen and bile duct problems such as cholecystectomy, portal hypertension and splenectomy. He is regularly sought after to provide a second opinion.
  
Professor Davidson is also Professor of Surgery and Head of Surgical Research at University College London (UCL). Following his promotion to personnel chair in surgery at UCL at the age of 39, he was the youngest professor of surgery in the UK at the time. During this time at UCL, right up to the present day, he has established a research programme investigating HPB disease with a large number of UK collaborators. Subsequently, he has produced a highly-successful team that has published over 420 peer-reviewed papers. 

Alongside his significant clinical academic work, Professor Davidson is also the course director for the UCL MSc in evidence-based healthcare and has extensively lectured about clinical trials and evidence-based healthcare. He has also been widely published in these two areas of interest. He has authored over 22 textbook chapters and supervised 34 successful PhD and MD degrees and trained a large amount of HPB and liver transplant surgeons.   

Professor Davidson is also an advisor to National Institute for Health and Care Excellence (NICE), the Healthcare Commission and the National Cancer Peer Review programme and chairs the National Institute for Health Research (NIHR) London grant-funding panel for Research for Patient Benefit (RfPB). He is currently a UK Editor for the UK Cochrane Group and director of the London editorial base for its HPB group. 


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