What is proton therapy, and what cancers can it treat?

Written in association with: Dr Crispin Hiley
Published:
Edited by: Conor Lynch

In this article below, highly regarded and experienced consultant clinical oncologist, Dr Crispin Hiley, provides us with an insightful guide on proton therapy, including how it benefits patients with lung cancer, and the potential side effects patients receiving the therapy may experience.

What is proton therapy?

It is a type of radiotherapy, given each day in small doses. It differs from conventional radiotherapy as it is a slghly different particle. This has some benefits. There are not as many side effects related to proton therapy as there are associated with conventional radiotherapy. Essentially, proton therapy reduces the side effects caused by radiotherapy.

 

What types of cancer can be treated with proton therapy?

Proton therapy is recommended in cancers where it is critical to reduce the side effects associated with the treatment of those cancers. Proton therapy is effective for paediatric cancer, or for patients who have cancers at the base of the skull.

 

Common cancers that are treated with proton therapy nowadays include:

 

  • head and neck cancers
  • breast cancer
  • certain types of lung cancer

 

What are the potential side effects of proton therapy?

Fatigue, cough, and problems with swallowing are all potential side effects.

 

When is proton therapy indicated for patients with lung cancer?

Proton therapy is very effective when it comes to treating non-small cell lung cancer, with early lung cancers, as well as patients with locally advanced lung cancers. It can also be useful for patients with mesothelioma, and also for patients who need radiotherapy following surgery for an enlargement of the thymic gland in the front part of the chest.

 

 

If you would like to book a consultation with Dr Crispin Hiley, you can do so via his Top Doctors profile here today

By Dr Crispin Hiley
Clinical oncology

Dr Crispin Hiley is an internationally recognised expert in oncology, bringing cutting-edge science and compassionate care to his patients. Privately practising at London Cromwell Hospital, LOC (Leaders in Oncology Care) at The Harley Street Clinic - HCA Healthcare and Proton International @ UCLH, he specialises in all the different kinds of lung cancer and also possesses a significant amount of expertise in chemotherapy, cancer immunotherapy, radiotherapy and proton beam therapy, as well as mesothelioma, amongst many others.

As an Associate Professor in Oncology at University College London and a Consultant Oncologist at University College London Hospital, Dr Hiley is at the forefront of cancer treatment and research. He also serves as the Clinical Director for Lung Cancer at GenesisCare UK, which offers private healthcare across 14 specialist centres in the UK.

Dr Hiley is dedicated to providing personalised care tailored to each patient's unique needs. He is available for private consultations in London and offers comprehensive chemotherapy and radiotherapy services across the UK. For patients who prefer treatment at home, he can arrange for chemotherapy to be administered where appropriate.

Specialising in non-surgical treatments for lung cancer, Dr. Hiley is an expert in chemotherapy, immunotherapy and targeted therapy, alongside radiotherapy, including advanced techniques such as volumetric arc therapy (VMAT), intensity modulated radiotherapy (IMRT) and image guided radiotherapy (IGRT) as well as proton therapy and stereotactic radiotherapy (SBRT).

Through his work in clinical trials and translational research Dr Hiley has published important research in the mechanism of resistance to EGFR inhibitors such as Osimertinin and immunotherapy such as Atezolizumab and Pembrolizumab.

As the UCLH Lead for Lung Proton Therapy, Dr Hiley was the first oncologist in the UK to treat lung cancer patients with this cutting-edge technology. He is also the chief investigator of the HIT-MESO trial, which explores the use of proton beam radiotherapy for mesothelioma patients. Through his role with Proton International@UCLH, Dr Hiley offers advanced proton therapy treatments for private patients.

Dr Hiley’s expertise extends beyond lung cancer. He specializes in stereotactic radiotherapy (SBRT) for oligo metastatic and oligo progressive diseases in various cancers, including breast, prostate and colorectal, gynaecological, sarcoma and lung.

He utilises state-of-the-art technology, including MRI-guided SABR with the ViewRay MRIdian system, to treat challenging tumour lesions. Additionally, he offers reirradiation therapy for patients who have previously undergone radiotherapy.

Dr Hiley graduated with honours from the University of Manchester in 2005 and has trained at prestigious institutions such as the Christie Hospital, MD Anderson Cancer Centre, Kings College, and the Royal Marsden. He holds a PhD from the University of London and has completed postdoctoral research fellowships at the Francis Crick Institute and the UCL Cancer Institute.

As a consultant since 2018, Dr Hiley leads the clinical oncology lung team at UCLH. His roles include UCLH Lead for Lung Proton Therapy, Deputy Lead of Clinical Trials for the CRUK Lung Cancer Centre of Excellence and NIHR Clinical Research Network Specialty Research Lead in Radiotherapy for North London.

He heads a research group focused on understanding resistance to cancer treatments and is the principal investigator for numerous clinical trials. His work has been published in leading journals such as NEJM, The Lancet, Nature, and Cell. Dr Hiley also contributed to the Royal College of Radiologists Consensus Statement on Radiotherapy for Lung Cancer which defines the standard of practice in the UK.

For more details and to book a consultation with Dr Hiley, you can arrange a consultation with him at London Cromwell Hospital or at LOC (Leaders in Oncology Care) at The Harley Street Clinic - HCA Healthcare. Just select the location and time in the 'REQUEST APPOINTMENT NOW' box on the right-hand side of this page.

Dr Crispin Hiley combines world-class expertise with compassionate care to provide the best possible outcomes for his patients. If you’re seeking a top oncologist in the UK, he is here to help.

View Profile

Overall assessment of their patients


  • Related procedures
  • Prostate cancer
    Breast cancer
    Bone cancer
    Nervous system malformations
    Brain tumour
    Bone marrow cancers
    Testicular cancer
    Thyroid cancer
    Adrenal glands cancer
    Neuro-oncology
    This website uses our own and third-party Cookies to compile information with the aim of improving our services, to show you advertising related to your preferences as well analysing your browsing habits. You can change your settings HERE.