DARWIN II: deciphering anti-tumor response & resistance to IO w/ intratumour heterogeneity in NSCLC See more
Crispin Hiley, PhD, UCL Cancer Institute, London, UK, shares an overview of the Phase II DARWIN II trial (NCT02314481), a multicenter, molecularly stratified trial designed to investigate how intratumor heterogeneity influences treatment response in patients with NSCLC. The DARWIN II trial enrolled 65 patients with metastatic NSCLC who had previously participated in the TRACERx Lung Cancer observational cohort study. They received atezolizumab or atezolizumab with chemotherapy. Multi-omic analysis of primary tumor and relapse biopsies revealed that a high clonal mutation burden was associated with a significantly improved response. Novel molecular features, including intratumor heterogeneity of the transcriptome and DNA methylation, were also linked to immunotherapy response. This study marks the first to prospectively show that clonal mutations and specific molecular features can predict immunotherapy outcomes in patients with NSCLC. This interview took place at the European Society for Medical Oncology (ESMO) 2023 Congress in Madrid, Spain.
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Lung cancer: what are the newest treatment options available? - Online interview See more
In this revealing online interview, Dr Crispin Hiley, a revered London-based consultant clinical oncologist, reveals what the most common causes of lung cancer are, and details the newest lung cancer treatment options that have recently become available.
00:00 What are the main early warning signs of lung cancer?
01:28 Can you detail the newest treatment options available for lung cancer?
03:10 How is it diagnosed?
05:12 What are the known causes of lung cancer?
06:37 How does/can lung cancer affect one’s daily life?
07:38 How is lung cancer treated and what are the chances of survival through these various treatment options?
To book a consultation with Dr Hiley, simply go to his Top Doctors profile here today: https://www.topdoctors.co.uk/doctor/crispin-hiley
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