Barrett's oesophagus

What is Barrett's oesophagus?

Barrett's oesophagus (spelt “Barrett’s esophagus” in the US) is a condition in which the tissue that lines the bottom of the oesophagus undergoes a change, usually in response to acid reflux from the stomach. It is a relatively common complication of gastro-oesophageal reflux disease (GORD).

Normally, the oesophagus is lined with squamous epithelial cells. However, exposure to stomach acid regurgitating up into the gullet can inflame and damage the cells. This leads to metaplasia, whereby the cells change into a different kind of cell, in this case columnar cells that are usually found in the lower digestive tract. These cells better resist the stomach acid, protecting the oesophagus.

However, symptoms of reflux can still bother the patient, and in a small number of cases, the cells can become cancerous. For this reason, Barrett’s oesophagus is regarded as a premalignant condition and although the proportion of cases that lead to oesophageal cancer is small, the condition should be monitored once diagnosed.

Microscopic image of Barrett's oesophagus

What are the symptoms of Barrett's oesophagus?

Barrett's oesophagus itself does not produce symptoms. However, it is almost always caused by acid reflux and this can cause a number of other symptoms:

 

What are the causes of Barrett's oesophagus?

Barrett’s oesophagus is closely associated with gastric reflux (also known as acid reflux or gastro-oesophageal reflux). This is a phenomenon where stomach acid splashes back up into the oesophagus, usually due to a problem with the ring of muscle that separates the oesophagus from the stomach (the gastro-oesophageal sphincter). If this sphincter loses tone and is unable to close, stomach acid is able to regurgitate back up.

If the patient experiences long-term acid reflux, this is known as gastro-oesophageal reflux disease (GORD). Around 1 in 10 patients with GORD will develop Barrett’s oesophagus.

The exact mechanism that causes Barrett’s oesophagus isn’t fully understood, as not all patients with acid reflux develop the condition.

 

Can Barrett’s oesophagus be prevented?

Early diagnosis and effective treatment of acid reflux or GORD can significantly reduce the risk of Barrett's oesophagus developing.

 

What is the treatment for Barrett’s oesophagus?

The first line of treatment for Barrett’s oesophagus involves managing the symptoms of acid reflux. This may involve the following measures:

  • Acid-suppressing medication, such as antacids, proton pump inhibitors, etc.
  • Avoid tobacco, alcohol and other substances that can affect the oesophagus
  • Avoid spicy or acidic food
  • Lose weight

Barrett’s oesophagus should be monitored closely via endoscopy to check for signs that the Barrett’s cells are progressing to cancer, in which case they will need immediate treatment.

If the cells become cancerous, the following procedures serve to remove the harmful tissue:

  • Radiofrequency ablation – an electrode at the end of an endoscope applies an electrical current to the affected area, destroying the malignant cells, which allows normal cells to grow in their place.
  • Endoscopic mucosal resection (EMR) – a thin wire called a snare on the end of an endoscope is used to remove malignant cells.
  • Surgical resection - more extensive surgery that may require admission to the ICU. The surgeon removes the affected part of the oesophagus and joins the stomach to the remaining part.
  • Photodynamic therapy: It involves the use of a laser device or oesophageal balloon together with a medication.
  • Cryotherapy
  • Other types of procedures using high energy to destroy cancerous cells.
 10-24-2023
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Barrett's oesophagus

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Dr Aathavan Loganayagam - Gastroenterology

Created on: 02-10-2017

Updated on: 10-24-2023

Edited by: Karolyn Judge

What is Barrett's oesophagus?

Barrett's oesophagus (spelt “Barrett’s esophagus” in the US) is a condition in which the tissue that lines the bottom of the oesophagus undergoes a change, usually in response to acid reflux from the stomach. It is a relatively common complication of gastro-oesophageal reflux disease (GORD).

Normally, the oesophagus is lined with squamous epithelial cells. However, exposure to stomach acid regurgitating up into the gullet can inflame and damage the cells. This leads to metaplasia, whereby the cells change into a different kind of cell, in this case columnar cells that are usually found in the lower digestive tract. These cells better resist the stomach acid, protecting the oesophagus.

However, symptoms of reflux can still bother the patient, and in a small number of cases, the cells can become cancerous. For this reason, Barrett’s oesophagus is regarded as a premalignant condition and although the proportion of cases that lead to oesophageal cancer is small, the condition should be monitored once diagnosed.

Microscopic image of Barrett's oesophagus

What are the symptoms of Barrett's oesophagus?

Barrett's oesophagus itself does not produce symptoms. However, it is almost always caused by acid reflux and this can cause a number of other symptoms:

 

What are the causes of Barrett's oesophagus?

Barrett’s oesophagus is closely associated with gastric reflux (also known as acid reflux or gastro-oesophageal reflux). This is a phenomenon where stomach acid splashes back up into the oesophagus, usually due to a problem with the ring of muscle that separates the oesophagus from the stomach (the gastro-oesophageal sphincter). If this sphincter loses tone and is unable to close, stomach acid is able to regurgitate back up.

If the patient experiences long-term acid reflux, this is known as gastro-oesophageal reflux disease (GORD). Around 1 in 10 patients with GORD will develop Barrett’s oesophagus.

The exact mechanism that causes Barrett’s oesophagus isn’t fully understood, as not all patients with acid reflux develop the condition.

 

Can Barrett’s oesophagus be prevented?

Early diagnosis and effective treatment of acid reflux or GORD can significantly reduce the risk of Barrett's oesophagus developing.

 

What is the treatment for Barrett’s oesophagus?

The first line of treatment for Barrett’s oesophagus involves managing the symptoms of acid reflux. This may involve the following measures:

  • Acid-suppressing medication, such as antacids, proton pump inhibitors, etc.
  • Avoid tobacco, alcohol and other substances that can affect the oesophagus
  • Avoid spicy or acidic food
  • Lose weight

Barrett’s oesophagus should be monitored closely via endoscopy to check for signs that the Barrett’s cells are progressing to cancer, in which case they will need immediate treatment.

If the cells become cancerous, the following procedures serve to remove the harmful tissue:

  • Radiofrequency ablation – an electrode at the end of an endoscope applies an electrical current to the affected area, destroying the malignant cells, which allows normal cells to grow in their place.
  • Endoscopic mucosal resection (EMR) – a thin wire called a snare on the end of an endoscope is used to remove malignant cells.
  • Surgical resection - more extensive surgery that may require admission to the ICU. The surgeon removes the affected part of the oesophagus and joins the stomach to the remaining part.
  • Photodynamic therapy: It involves the use of a laser device or oesophageal balloon together with a medication.
  • Cryotherapy
  • Other types of procedures using high energy to destroy cancerous cells.
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