What is it and what does it analyse?

The CA-125 test measures the amount of a protein called CA-125 (cancer antigen 125) in a blood sample. This protein serves as a tumour marker.

What is it used for?

Ovarian cancer monitoring: This is the most common use of the test. It helps evaluate whether treatment is effective and if ovarian cancer has recurred. Evaluation of pelvic masses: When a suspicious mass is detected on imaging (such as ultrasound), CA-125 levels are checked along with other tests to determine if the mass could be ovarian cancer.

In individuals with a family history of ovarian cancer, the test may be performed along with others to detect early signs.

Why is this analysis performed?

To assess treatment response and cancer recurrence, as well as to investigate suspicious pelvic masses.

When should this analysis be carried out?

During treatment to monitor response, after treatment to check for cancer recurrence, and when pelvic masses are present.

Is any sample required?

A blood sample.

Is any special preparation needed?

No specific preparation is required.

How is it used?

The amount of CA-125 in the blood is measured. A normal CA-125 result is less than 35 U/ml.

What do abnormal values indicate?

Elevated CA-125 levels may be present in individuals with ovarian cancer, but they can also occur in other non-cancerous conditions such as endometriosis. An abnormal result does not definitively rule out ovarian cancer, as levels can be low in early stages.