What is being analysed?

Chymotrypsin analysis involves the measurement of chymotrypsin levels in biological samples, typically serum or stool samples. Chymotrypsin is an enzyme produced by the pancreas that aids in the digestion of proteins in the small intestine.

What does the result mean?

The result of chymotrypsin analysis provides insight into pancreatic function. Low levels of chymotrypsin may indicate pancreatic insufficiency, which can lead to malabsorption of nutrients and digestive disorders.

Why do the analysis?

Chymotrypsin analysis is crucial for diagnosing pancreatic disorders such as chronic pancreatitis, cystic fibrosis, and pancreatic cancer. Early detection allows for prompt treatment and management of these conditions, improving patient outcomes.

When to do the analysis?

Chymotrypsin analysis is typically performed when there are symptoms suggestive of pancreatic dysfunction, such as abdominal pain, steatorrhea (fatty stools), weight loss, and nutrient deficiencies. It may also be part of routine screening for certain high-risk populations, such as individuals with a family history of pancreatic disease or cystic fibrosis.

What sample is required?

Serum or stool samples are commonly used for chymotrypsin analysis. Serum samples are obtained through venipuncture, while stool samples can be collected at home and brought to the laboratory for testing.

Is any type of prior preparation necessary?

For serum samples, no special preparation is usually required. However, patients may be instructed to fast for a certain period before the blood draw. Stool samples may require specific collection instructions to ensure accuracy.

How is it used?

Chymotrypsin analysis is used as a diagnostic tool to assess pancreatic function. It helps healthcare providers confirm or rule out pancreatic disorders and guide treatment decisions. Additionally, serial measurements of chymotrypsin levels may be used to monitor disease progression and response to treatment.

Normal values and interpretation:

What does it mean to have altered values?

Low chymotrypsin levels: Low levels of chymotrypsin may indicate pancreatic insufficiency, which can result from conditions such as chronic pancreatitis, cystic fibrosis, or pancreatic cancer. Patients with low chymotrypsin levels may experience symptoms such as steatorrhea, weight loss, and nutrient deficiencies.

High chymotrypsin levels: Elevated chymotrypsin levels are less common but may be seen in conditions such as acute pancreatitis or pancreatic duct obstruction. Additional testing and clinical correlation are necessary to determine the underlying cause of elevated chymotrypsin levels.