What is being analysed?

Epidermal growth factor receptor (EGFR) is a protein found on the surface of cells, particularly in the skin and lungs. This analysis examines the presence and activity levels of EGFR, which play crucial roles in cell growth, proliferation, and survival.

What does the result mean?

The result of EGFR analysis indicates the expression levels or mutations present in the EGFR protein. This information helps in understanding the potential response to certain medications, particularly in cancer treatment.

Why do the analysis?

EGFR analysis is performed primarily to guide treatment decisions, especially in cancer therapy. Certain cancers, such as non-small cell lung cancer (NSCLC), may exhibit mutations or overexpression of EGFR, making targeted therapies more effective.

When to do the analysis?

EGFR analysis is typically conducted when a patient is diagnosed with cancer, especially NSCLC. It may also be performed during the course of treatment to monitor response or when disease progression is suspected.

What sample is required?

For EGFR analysis, a tissue sample (biopsy) or blood sample may be required, depending on the specific test being performed. Tissue samples are often obtained via biopsy during diagnosis or surgery.

Is any type of prior preparation necessary?

Prior preparation may vary depending on the type of sample being collected. For tissue biopsy, patients may need to avoid certain medications that can affect blood clotting. Blood samples usually do not require any special preparation.

How is it used?

EGFR analysis is used to determine the appropriate treatment approach for patients with certain types of cancer. It helps oncologists decide whether targeted therapies, such as EGFR inhibitors, are suitable and likely to be effective.

Normal values:

Normal values for EGFR expression levels or mutations may vary depending on the specific test and the laboratory performing the analysis. Generally, low or normal EGFR expression without mutations is considered normal.

Altered values:

Altered values in EGFR analysis may indicate mutations or overexpression of the EGFR protein. In cancer, such alterations can lead to uncontrolled cell growth and may indicate a potential response to targeted therapies. However, altered EGFR values can also occur in non-cancerous conditions, so further evaluation is often necessary for proper interpretation.

EGFR Analysis Values:

This table provides a simplified overview of EGFR analysis values and their interpretation. Actual results may vary depending on the specific test methodology and laboratory standards.