Lymphoma

What is lymphoma?

Lymphoma is a group of blood cancers developing from lymphocytes, which are the cells that defend the body in the immune system. This proliferation takes place in the nodules or lymph nodes, although sometimes it also affects the spleen or liver. Thus, it is a cancer that originates in the lymphatic tissue.

As a result of the disease, there is an impairment of the immune system, which accentuates as the disease further spreads. If the bone marrow has been affected, it can lead to anaemia or other changes in the blood cells.

Lymphoma accounts for about 3 to 4 per cent of all cancers around the world.

A blood test plays a part in the lymphoma diagnosis process

What are the different types of lymphoma?

There are two main types of lymphoma:

  1. Hodgkin's lymphoma or Hodgkin's disease
  2. Non-Hodgkin's lymphoma

However, there is a new classification called the REAL System (Revised European American Lymphoma Classification), which divides types of lymphoma according to their clinical behaviour into three categories:

  • Indolent lymphoma: This grows slowly. Patients with this type of lymphoma can live for many years without any treatment and without presenting the problems derived from the disease. In fact, in many of these patients treatment is discouraged if they do not develop symptoms.
  • Aggressive or highly-aggressive lymphoma: This type of lymphoma grows faster than the previously mentioned types. It's essential to treat patients otherwise life expectancy is reduced to weeks or months. Luckily this lymphoma responds well to chemotherapy and many of them are curable.

What are the symptoms?

Normal lymphoma manifests through protruding lymph nodes, which increase in size and are visible in areas such as the neck, armpits or groins. However, when they appear in less accessible areas such as the abdomen or the mediastinum (the space in your chest which holds your heart and other important structures) they can go unnoticed, thus making it difficult to diagnose until symptoms do not usually appear. These symptoms include, among others:

  • Fever greater than 38 degrees
  • Profuse sweating at night
  • Unexplained weight loss (more than 10 per cent in six months)
  • Enlargement of the spleen

What causes lymphoma?

Presently, the exact causes that trigger lymphoma are unknown except in some cases that are related to infections caused by bacteria such as helicobacter pylori and borrelia or the Epstein-Barr virus (EBV).

Can it be prevented?

There's no way to prevent lymphoma. However, experts recommend leading a healthy lifestyle, which could reduce the risk of its appearance, but there is no direct relationship. Other recommendations are to avoid obesity, smoking and cardiovascular risk factors, not because they can cause lymphoma, but because a person with comorbidities (a primary disease or condition that co-occurs with, but is often independent of, another disease) is less likely to overcome favourably aggressive treatment, such as chemotherapy.

How is lymphoma treated?

The treatment of lymphoma depends on the prognosis, the age of the patient and his general state of health. A good preliminary study should be done to know the extent of the disease and subsequently decide the best treatment.

The most used treatments are:

  • Alkylating agents, which directly attack DNA to prevent the reproduction of cancer cells;
  • Rituximab is a type of monoclonal antibody indicated for non-Hodgkin lymphoma or relapses;
  • Chemotherapy;
  • Haematopoietic stem cell transplantation.
 10-18-2023
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Lymphoma

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Dr Michael Potter - Haematology

Created on: 03-12-2013

Updated on: 10-18-2023

Edited by: Karolyn Judge

What is lymphoma?

Lymphoma is a group of blood cancers developing from lymphocytes, which are the cells that defend the body in the immune system. This proliferation takes place in the nodules or lymph nodes, although sometimes it also affects the spleen or liver. Thus, it is a cancer that originates in the lymphatic tissue.

As a result of the disease, there is an impairment of the immune system, which accentuates as the disease further spreads. If the bone marrow has been affected, it can lead to anaemia or other changes in the blood cells.

Lymphoma accounts for about 3 to 4 per cent of all cancers around the world.

A blood test plays a part in the lymphoma diagnosis process

What are the different types of lymphoma?

There are two main types of lymphoma:

  1. Hodgkin's lymphoma or Hodgkin's disease
  2. Non-Hodgkin's lymphoma

However, there is a new classification called the REAL System (Revised European American Lymphoma Classification), which divides types of lymphoma according to their clinical behaviour into three categories:

  • Indolent lymphoma: This grows slowly. Patients with this type of lymphoma can live for many years without any treatment and without presenting the problems derived from the disease. In fact, in many of these patients treatment is discouraged if they do not develop symptoms.
  • Aggressive or highly-aggressive lymphoma: This type of lymphoma grows faster than the previously mentioned types. It's essential to treat patients otherwise life expectancy is reduced to weeks or months. Luckily this lymphoma responds well to chemotherapy and many of them are curable.

What are the symptoms?

Normal lymphoma manifests through protruding lymph nodes, which increase in size and are visible in areas such as the neck, armpits or groins. However, when they appear in less accessible areas such as the abdomen or the mediastinum (the space in your chest which holds your heart and other important structures) they can go unnoticed, thus making it difficult to diagnose until symptoms do not usually appear. These symptoms include, among others:

  • Fever greater than 38 degrees
  • Profuse sweating at night
  • Unexplained weight loss (more than 10 per cent in six months)
  • Enlargement of the spleen

What causes lymphoma?

Presently, the exact causes that trigger lymphoma are unknown except in some cases that are related to infections caused by bacteria such as helicobacter pylori and borrelia or the Epstein-Barr virus (EBV).

Can it be prevented?

There's no way to prevent lymphoma. However, experts recommend leading a healthy lifestyle, which could reduce the risk of its appearance, but there is no direct relationship. Other recommendations are to avoid obesity, smoking and cardiovascular risk factors, not because they can cause lymphoma, but because a person with comorbidities (a primary disease or condition that co-occurs with, but is often independent of, another disease) is less likely to overcome favourably aggressive treatment, such as chemotherapy.

How is lymphoma treated?

The treatment of lymphoma depends on the prognosis, the age of the patient and his general state of health. A good preliminary study should be done to know the extent of the disease and subsequently decide the best treatment.

The most used treatments are:

  • Alkylating agents, which directly attack DNA to prevent the reproduction of cancer cells;
  • Rituximab is a type of monoclonal antibody indicated for non-Hodgkin lymphoma or relapses;
  • Chemotherapy;
  • Haematopoietic stem cell transplantation.
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