T-cell receptor gene rearrangement
What is analysed?
T-cell receptor gene rearrangement analysis examines the genetic rearrangements that occur in T-cell receptor genes. These rearrangements are crucial for the development of T-cell receptors, which play a central role in the immune system.
What does the result mean?
The result of T-cell receptor gene rearrangement analysis indicates whether there are normal patterns of gene rearrangement or if there are abnormalities, such as clonal expansion of T-cells, which may suggest a lymphoproliferative disorder.
Why undergo the analysis?
T-cell receptor gene rearrangement analysis is performed to assess clonality in lymphoid proliferations, helping in the diagnosis and monitoring of lymphoid malignancies.
When to undergo the analysis?
T-cell receptor gene rearrangement analysis is typically requested when there is suspicion of lymphoproliferative disorders, such as lymphoma or leukaemia.
What sample is required?
Tissue samples, such as lymph node biopsies or bone marrow aspirates, are often required for T-cell receptor gene rearrangement analysis.
Is any prior preparation necessary?
No specific preparation is usually necessary for T-cell receptor gene rearrangement analysis. However, patients should inform healthcare providers about any medications they are taking.
How is it used?
T-cell receptor gene rearrangement analysis involves molecular techniques such as PCR (Polymerase Chain Reaction) to amplify and analyse the DNA sequences of T-cell receptor genes.
What are the normal values?
Normal values for T-cell receptor gene rearrangement analysis involve the presence of a polyclonal pattern, indicating diverse T-cell populations.
T-cell receptor gene rearrangement analysis
| Parameter | Normal value |
| Gene rearrangement pattern | Polyclonal |
This table summarises the normal values observed in T-cell receptor gene rearrangement analysis, helping in the interpretation of test results.
What do altered values signify?
Altered values, such as monoclonal patterns or clonal expansions, may indicate the presence of a lymphoproliferative disorder, including lymphoma or leukaemia.